Table 1. Pharmacological activities of SALMFamide peptides on the apical muscle of starfishes Asterias amurensis and Patiria pectinifera

Tissue A. amurensis P. pectinifera
TC (M) Emax ± SEM (%) TC (M) Emax ± SEM (%)
SALMFa-S1 10–8 19.92 ± 0.99 10–8 14.82 ± 1.38
SALMFa-S2 5 × 10–8 22.10 ± 2.77 5 × 10–8 13.61 ± 1.53
SALMFa-A 10–8 11.41 ± 0.61 10–7 8.86 ± 0.90
SALMFa-B 10–8 15.32 ± 0.98 10–8 14.00 ± 1.50
TC is the concentration at which each neuropeptide started to exert myoactivity. The Emax is based on the best-fit top value on a dose-depend curve constructed by the in vitro bioassay and estimated as a relative percentage of the muscle maximum contraction induced by acetylcholine 5 × 10–6 M on apical muscle. TC, threshold concentration; Emax, peptide efficacy.