| Skate cartilage | Papain and thermal hydrolysis | Improve free radical scavenging activity | Li et al., 2021 |
| Pacific white shrimp mix by-products (cephalothorax, shells, and pleopods) | Trypsin autolytic hydrolysis | Inhibit oxidative reactions by scavenging hydroxyl radicals | Nikoo et al., 2021b |
| Various marine fish by-products (skin, heads, and skeletons) | Collagen hydrolysis | Potential antioxidant ingredients for functional foods and pharmaceuticals industry | Zamorano-Apodaca et al., 2020 |
| Abalone viscera | Enzymatic hydrolysis (papain, trypsin, neutral protease, alkali protease, pepsin) | Potential source of antioxidant | Zhou et al., 2012 |
| Squid pen | Trypsin hydrolysis | Enhance antioxidant activity | Shavandi et al., 2017 |
| Tuna dark muscle | Orientase and protease XXIII hydrolysis | Generate strong DPPH radical-scavenging activity and antioxidative activity | Hsu, 2010 |
| n-Hexane/ethanol extraction | Inhibit the growth of obesity related diseases through the suppression of hepatic triacylglycerol and cholesterol accumulation | Maeda et al., 2017 |
| Stripped weakfish by-products (skin and bone) | Alcalase and protamex hydrolysis | Potential natural antimicrobial and antioxidant preservatives in food | Lima et al., 2019 |
| Bycatch shrimp Oratosquilla woodmasoni waste | Thermolysin hydrolysis | Produce ACE-I inhibition peptide that could be utilized as anti-hypertentsive and free radicals prevention | Joshi et al., 2020 |
| Pearl oyster shell | Orientase hydrolysis | Potent ACE inhibitory activity | Sasaki et al., 2019 |
| Squid skin | Pepsin hydrolysis | Good source of ACE inhibition peptide | Lin et al., 2012 |
| Tuna blood | Enzymatic hydrolysis (alcalase, neutrase, flavourzyme) | Exhibit strong antioxidant and ACE inhibitory activity | Mongkonkamthorn et al., 2020 |
| Shrimp shell | Protease hydrolysis | Demonstrate higher ACE inhibitory activity compared to hypertension drug (captopril) | Mechri et al., 2020 |
| Marine catfish skin | Chemical extraction | Possess anticancer activity against human colon cancer line | Raja et al., 2020 |
| Octopus ink | Dichloromethane extraction | Potential immunomodulatory and anti-proliferative against colorectal and breast cancer | Hernandez-Zazueta et al., 2021 |
| Cuttlefish posterior salivary gland toxin | SDS-PAGE extraction | Exhibit great cytotoxicity against breast cancer and inhibit penetration of metastatic cells | Karthik et al., 2017 |
| Rainbow trout skin | Flavourzyme and alcalase hydrolysis | Possess antioxidant and anticancer activities | Yaghoubzadeh et al., 2020 |
| Flathead by-products (head, backbone, skeleton) | AFP hydrolysis | Potent antioxidant and cancer cells cytotoxic agents | Nurdiani et al., 2017 |
| Blue mussel by-product | Protamex hydrolysis | Exhibit inhibitory activity against cancer cells | Beaulieu et al., 2013 |
| Sardine by-products (viscera, heads, skins, and edges) | Isoelectric precipitation | Improve LCAT activity and reduce complications related to obesity | Affane et al., 2018 |
| Skate skin | Collagen extraction | Demonstrate anti-obesity impact | Woo et al., 2018 |
| Squid by-products (viscera and ink sacs) | Protease hydrolysis | Suppress the activity of gram-negative and gram-positive bacteria | Jiang et al., 2018 |
| Salmon by-products (bones, fins, and tails) | Protease hydrolysis | Enhance copper-binding capacity | Vo & Pham, 2020 |
| Giant croaker skin | Neutral protease hydrolysis | Potential immunomodulatory agent | Yu et al., 2020 |