Table 1. Collagenase, elastase, and hyaluronidase inhibitory effects of brown seaweed extracts

Brown seaweeds	Total phenolic contents (PGE mg/g)	IC50 values for collagenase inhibition (μg/mL)	IC50 values for elastase inhibition (μg/mL)	IC50 values for hyaluronidase inhibition (μg/mL)
Carpomitra costata	9.66 ± 0.16i	> 100	> 1,000	> 250
Desmarestia tabacoides Okamura	5.24 ± 0.06l	> 100	> 1,000	> 250
Ecklonia cava	98.65 ± 0.40b	95.08 ± 0.78	465.13 ± 15.63	219.16 ± 4.73
Eisenia bicyclis	96.81 ± 0.56b	> 100	> 1,000	212.88 ± 4.10
Ishige foliacea	32.99 ± 0.53g	> 100	> 1,000	> 250
Ishige okamurae	57.37 ± 0.94d	> 100	> 1,000	> 250
Padina gymnospora	66.94 ± 0.30c	> 100	260.05 ± 26.71	246.45 ± 3.59
Sargassum coreanum	96.73 ± 0.81b	> 100	388.65 ± 18.64	225.17 ± 4.52
Sargassum horneri	6.85 ± 0.13k	> 100	> 1,000	> 250
Saccharina japonica	3.11 ± 0.04m	> 100	> 1,000	> 250
Sargassum macrocarpum	14.64 ± 0.23h	> 100	> 1,000	> 250
Sargassum micracanthum	51.63 ± 0.43e	> 100	> 1,000	> 250
Sporochnus radiciformis	8.53 ± 0.05j	97.02 ± 1.95	> 1,000	> 250
Sargassum serratifolium	34.47 ± 0.20f	87.58 ± 0.49	> 1,000	> 250
EGCG1) (mM)		0.17 ± 0.01	2.34 ± 0.07	0.25 ± 0.00

Positive control.
Small letters presented differences between treatments in each column.
EGCG, epigallocatechin gallate; IC₅₀, half-maximal inhibitory concentration; PGE, phloroglucinol equivalent.