Table 3. Summarized ADME properties based on SwissADME and BOILED-egg model

Lipinski’s rule of five
Parameter	Acceptable range	Result
Molecular Weight (g/mol)	≤ 500	412.69 g/mol
Lipophilicity (MLogP)	≤ 4.15	6.62
Hydrogen bond donors (NH/OH)	≤ 5	1
Hydrogen bond acceptors (N/O)	≤ 10	1
Rule violation	≤ 1	1
Molecular drug-likeness	Yes, 1 violation
BOILED-egg predictions
Parameter		Result
Passive absorption in the GI tract		No
BBB permeant		No
Lipinski’s rule of five
Parameter	Acceptable range	Result
Molecular weight (g/mol)	≤ 500	412.69 g/mol
Lipophilicity (MLogP)	≤ 4.15	6.62
Hydrogen bond donors (NH/OH)	≤ 5	1
Hydrogen bond acceptors (N/O)	≤ 10	1
Rule violation	≤ 1	1
Molecular drug-likeness	Yes, 1 violation
BOILED-egg predictions		Result
Passive absorption in the GI tract		No
BBB permeant		No

ADME, absorption, distribution, metabolism, and excretion; BBB, blood-brain barrier; BOILED-egg, brain or Intestinal estimated permeation; GI, gastrointestinal.