Table 10. Comparison of chromophore optimized conditions through response surface methodology (RSM) with machine learning approaches

SI no.	Exposure to ultrasound (min)	Temperature of the solvent (°C)	Collagen – (R2 value)
			Experimental	RSM	ANN	kNN	Random forest
1	39.77	59.86	2.6643	2.696 (0.76)	2.663 (0.899)	2.696 (0.371)	2.568 (0.816)

ANN, artificial neural network; kNN, k-nearest neighbors.